Lytic Chitin Monooxygenases

Science

Worth a look when you cover this topic.

Impact 55.6 · Consider · Confidence 100

• Updated EC classification digits (1 14 99 53) and expanded structural context for LPMOs; new references appended.
• Provides new details on substrate specificity and active-site architecture.

Add: In the enzyme class number 1 14 99 53 the 1 is for oxidoreductase meaning a redox active enzyme The 14. Add: center and shares large similarities with other LPMOs including a copper cation Although the differences between LPMOs that use chitin and those that use cellulose as substrates are not well known the general enzyme structure is similar between the two A few amino acids changed near and around the active site can alter the activity to select chitin over cellulose or vice versa Typical hydrolases that cleave sugars require a polysaccharide chain to be removed from a crystalline lattice like chitin before they can use it Lytic chitin monooxygenases can cleave the glycosidic bonds in chitin directly however because of their structure The active site lies on a flat surface allowing the enzyme to bind the chitin lattice without having to isolate individual polysaccharide chains The structures o

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